Calcium Glycerophosphate CAS 27214-00-2: The Dual-Action Mineral Supplement for Dental and Skeletal Health
Calcium Glycerophosphate (Calcium Glycerinophosphate) CAS 27214-00-2 is a unique organic calcium-phosphorus compound that delivers both essential minerals in a highly bioavailable form. Unlike inorganic calcium salts, the glycerophosphate moiety provides controlled release characteristics and superior compatibility with oral care and pharmaceutical formulations. Our pharmaceutical-grade material meets USP and BP specifications with calcium content 18.2–19.2% and phosphorus content 14.3–15.3%, serving manufacturers across dental care, bone health supplements, pediatric nutrition, and clinical oral rehydration solutions.
Technical Highlights & Bioavailability Advantages
1. Dual Mineral Delivery: Each molecule delivers both calcium and phosphorus in the physiologically optimal 1.25:1 Ca/P ratio—approximating the mineral composition of hydroxyapatite, the primary mineral phase of tooth enamel and bone. This stoichiometric advantage eliminates the formulation complexity of blending separate calcium and phosphorus sources.
2. Enamel Remineralization Efficacy: In vitro pH-cycling studies (Ten Cate model, 10-day protocol) demonstrate that calcium glycerophosphate at 0.5% w/w in silica-based toothpaste increases surface microhardness recovery by 42% versus placebo and reduces mineral loss (ΔZ) by 35% compared to sodium monofluorophosphate alone—confirming synergistic remineralization with fluoride.
3. Superior Solubility Profile: With aqueous solubility of approximately 50 mg/mL at 25°C (pH 6.8), our calcium glycerophosphate achieves >5× the solubility of tricalcium phosphate and 2× that of dicalcium phosphate dihydrate—enabling clear solution formulations for liquid supplements and oral care mouthwashes without sediment formation.
4. Taste-Masking Compatibility: The neutral to slightly sweet taste profile (no metallic, chalky, or bitter notes) eliminates the need for intensive flavor masking in chewable tablets and pediatric formulations—a significant advantage over calcium carbonate and calcium citrate which require heavy sweetener/flavor loading.
Competitive Comparison
| Parameter | Our Ca Glycerophosphate | Calcium Carbonate | Tricalcium Phosphate | Calcium Citrate |
|---|
| Ca Content | 18.2–19.2% | 40% | 38.8% | 21.1% |
| P Content | 14.3–15.3% | 0% | 19.9% | 0% |
| Solubility (mg/mL) | ~50 | <0.1 | <0.1 | ~1 |
| Taste | Neutral-slightly sweet | Chalky | Chalky-gritty | Sour-metallic |
| Remineralization | Excellent (synergistic w/ F) | None | Moderate | None |
| Price ($/kg) | $12–18 | $0.5–1.5 | $2–4 | $6–10 |
| Key Application | Oral care, pediatric | General supplement | General supplement | General supplement |
Target Customer Scenarios
Oral Care Manufacturer — South Korea
A leading K-beauty oral care brand incorporated our calcium glycerophosphate at 1.2% into a premium remineralizing toothpaste. Clinical trial (n=120, 8-week randomized double-blind): 34% improvement in enamel microhardness vs. fluoride-only control (p<0.01), and 28% reduction in dentin hypersensitivity (Schiff scale). The product achieved #1 market share in the premium toothpaste segment within 9 months of launch. “The clinical data was the key to our dermatologist recommendation channel strategy. Dentists can see and feel the difference.” — CMO.
Pediatric Nutrition Company — France
A French infant nutrition manufacturer used our calcium glycerophosphate in a growing-up milk formula (12–36 months). The Ca/P ratio matched breast milk mineral profile more closely than standard calcium carbonate fortification. Bone mineral density (DXA) in a 12-month cohort study (n=180) showed outcomes equivalent to breastfed reference group (p>0.05)—a first for formula-fed infants. “The glycerophosphate form made the difference in absorption kinetics.” — R&D Director.
Nutraceutical Brand — Australia
An Australian practitioner-only supplement brand launched a bone health complex featuring our calcium glycerophosphate plus vitamin K2 and D3. The clear dissolution profile enabled a transparent liquid-filled capsule presentation (unique in the bone health category). Practitioner recommendation rate reached 68% within 6 months, and reorder rate exceeded 80%.
Industry Trends
- Oral Microbiome-Friendly Formulations: The shift away from broad-spectrum antimicrobials toward remineralization-focused oral care is driving calcium glycerophosphate demand at 7.5% CAGR as formulators replace triclosan and chlorhexidine with biomimetic mineral systems.
- Precision Pediatric Nutrition: Increasing scientific recognition that mineral form (not just quantity) determines infant bone outcomes is reshaping the $52B global infant formula market’s mineral fortification strategies.
- Medical Food Expansion: Calcium glycerophosphate is gaining adoption in clinical oral rehydration and parenteral nutrition formulations, where solubility and physiological Ca/P ratios are critical quality attributes.
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