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Poly-L-Lactic Acid (PLLA) CAS 26811-96-1 Poly(L-lactide) Fine Powder Poly(L-lactide)
| MOQ: | 1gram |
| Standard Packaging: | 10g/bottle |
| Delivery Period: | 3-5 working days for stock, 15-20 days for bulk production |
| Payment Method: | T/T,L/C,Western Union,Trade Assurance |
| Supply Capacity: | 200 Tons per Month |
Poly-L-Lactic Acid (PLLA) CAS 26811-96-1
Product Introduction
Poly-L-lactic acid, also called Poly(L-lactide) or PLLA, CAS 26811-96-1, is a high-purity biodegradable polymer made from L-lactic acid. It belongs to the poly(α-hydroxy acid) family and offers excellent mechanical strength, controlled degradation rate, and non-toxic degradation products such as lactic acid, water, and carbon dioxide.
PLLA is a semi-crystalline polymer with a melting point around 170–185 °C and a glass transition temperature around 55–65 °C. It is available as white to off-white granules, powder, or fiber, with customizable intrinsic viscosity from 0.2 to 8.0 dL/g and molecular weight from 10,000 to 1,000,000 Da. Because of its slower degradation and high mechanical strength compared with PDLLA, PLLA is commonly used for long-term implantable medical devices and high-strength biodegradable products.
Physical and Chemical Specification
| Parameter | Specification | Test Method |
|---|---|---|
| CAS Number | 26811-96-1 | — |
| Product Name | Poly-L-lactic acid / Poly(L-lactide) / PLLA | — |
| Molecular Formula | (C₃H₄O₂)n | — |
| Synonyms | Poly[(2S)-2-hydroxypropanoic acid]; L-Polylactide | — |
| Appearance | White to off-white granules, powder, or fiber | Visual |
| Intrinsic Viscosity | 0.2–8.0 dL/g, customizable | Ubbelohde, chloroform, 25 °C |
| Molecular Weight (Mw) | 10,000–1,000,000 Da | GPC |
| Melting Point (Tm) | 170–185 °C | DSC |
| Glass Transition Temperature (Tg) | 55–65 °C | DSC |
| Density | 1.24–1.27 g/cm³ | ISO 1183 |
| Crystallinity | 35–45% after annealing | XRD / DSC |
| Residual L-lactide Monomer | ≤ 1.0%, customizable ≤ 0.5% | GC / HPLC |
| Residual Solvent | ≤ 0.5% | GC |
| Moisture Content | ≤ 0.5% | Karl Fischer |
| Heavy Metals | ≤ 10 ppm | ICP-MS |
| Catalyst Residue (Sn) | ≤ 100 ppm, or catalyst-free grade | ICP-MS |
| Sulfated Ash | ≤ 0.1% | Pharmacopoeia method |
| Tensile Strength | 40–70 MPa | ISO 527 |
| Elongation at Break | 2–10% | ISO 527 |
| Degradation Time | 12–36 months in vivo, depends on Mw and form | In vitro / in vivo |
| Solubility | Soluble in chloroform, dichloromethane; insoluble in water, ethanol | — |
| Storage Conditions | -20 °C to 4 °C, sealed, dry, protect from moisture | — |
Product Functions
- Biodegradability and Bioresorbability: PLLA hydrolyzes into lactic acid, which is metabolized by the body without toxic residues.
- Biocompatibility: Suitable for medical implants, tissue engineering, and medical delivery applications.
- Mechanical Strength: High tensile strength and modulus make PLLA suitable for load-bearing orthopedic devices.
- Controlled Degradation Rate: Degradation can be adjusted by molecular weight, crystallinity, and end-group chemistry.
- Thermal Processability: Can be processed by injection molding, extrusion, electrospinning, and 3D printing.
- Renewable and Environmentally Friendly: Derived from plant-based feedstocks, reducing dependence on fossil resources.
- Good Optical and Barrier Properties: Useful in packaging and film applications.
Application Areas
- Medical Implants: Bioabsorbable screws, plates, pins, rods, stents, and interference screws in orthopedics and craniofacial surgery.
- Medical Delivery: Microspheres, nanoparticles, and implants for controlled release of medicals, peptides, and anticancer medicals.
- Tissue Engineering: 3D scaffolds, membranes, and fibers for cell growth and tissue regeneration.
- Aesthetic Medicine: Poly-L-lactic acid dermal fillers for facial volume restoration and collagen stimulation.
- Surgical Sutures: Monofilament and braided absorbable sutures.
- 3D Printing: Biodegradable filaments and custom medical scaffolds.
- Packaging: Compostable films, food containers, and bottles.
- Textiles: Biodegradable fibers for apparel, hygiene, and agricultural applications.
Manufacturing Process
- Feedstock Preparation: Corn, cassava, or sugarcane starch is hydrolyzed to glucose, then fermented to produce L-lactic acid.
- Lactic Acid Purification: Impurities are removed to obtain high-purity L-lactic acid.
- Oligomerization: L-lactic acid is polycondensed under vacuum to form low molecular weight poly(L-lactic acid).
- Depolymerization: Catalytic thermal depolymerization produces L-lactide, the cyclic dimer.
- Lactide Purification: L-lactide is purified by recrystallization or distillation to high purity.
- Ring-Opening Polymerization: Purified L-lactide is polymerized under vacuum at 130–180 °C using tin octoate or other catalysts.
- Purification and Drying: Unreacted monomer, residual catalyst, and solvents are removed; the polymer is dried.
- Granulation and Packaging: The final PLLA is pelletized or milled, tested for intrinsic viscosity, molecular weight, and residual monomer, then packed under dry conditions.
Why Choose Us
- High Purity and Consistency: Low residual lactide monomer, stable intrinsic viscosity, and molecular weight batch-to-batch.
- Customization: Custom molecular weight, intrinsic viscosity, end groups, particle size, and copolymer grades.
- Quality Assurance: ISO 9001/GMP production facilities with complete COA, TDS, SDS, and regulatory support.
- Medical and Industrial Grades: Products suitable for medical devices, medicals, and industrial applications.
- Technical Support: R&D team supports formulation, processing, and application development.
- Reliable Supply: Global logistics, flexible MOQ, and on-time delivery.
- Competitive Pricing: Cost-effective supply from renewable feedstock-based bulk manufacturing.
FAQ
1. What is Poly-L-lactic acid (PLLA) CAS 26811-96-1?
Poly-L-lactic acid, CAS 26811-96-1, is a biodegradable, biocompatible polyester produced from renewable L-lactic acid. It is used in medical devices, controlled medical release, tissue engineering, and eco-friendly packaging.
2. Is PLLA biodegradable?
Yes. PLLA degrades by hydrolysis of ester bonds into lactic acid, which is then metabolized to water and carbon dioxide. Degradation time depends on molecular weight, crystallinity, and the surrounding environment.
3. What is the difference between PLLA and PDLLA?
PLLA is semi-crystalline, stronger, and degrades more slowly. PDLLA, made from DL-lactic acid, is amorphous and degrades faster because the random structure prevents crystallization.
4. How should PLLA be stored?
Store in sealed containers at -20 °C to 4 °C, away from moisture, heat, and direct sunlight. Use under dry conditions to prevent hydrolysis.
5. What is PLLA soluble in?
PLLA is soluble in chlorinated solvents such as chloroform and dichloromethane. It is insoluble in water, ethanol, and most aliphatic hydrocarbons.
6. What are the common applications of PLLA?
Medical implants such as screws and plates, surgical sutures, medical delivery microspheres, tissue engineering scaffolds, dermal fillers, 3D printing filaments, and compostable packaging.
7. Can you provide customized PLLA grades?
Yes. We offer custom intrinsic viscosity from 0.2 to 8.0 dL/g, molecular weight, particle size, and end-group modification for specific applications.
8. What is the minimum order quantity and lead time?
Typical MOQ is 1 kg for research grade and 25 kg for industrial or medical grade. Lead time is usually 7–15 days after order confirmation.
9. Is PLLA safe for medical use?
Medical-grade PLLA meets ISO 10993 biocompatibility requirements and is used in FDA-approved medical devices. We provide certificates and regulatory documentation.
10. How can I get a quote for PLLA CAS 26811-96-1?
Contact us with your required grade, intrinsic viscosity, molecular weight, quantity, and destination. We will provide a competitive quotation and samples when available.
Send us your active ingredient, target concentration and dosage form. We will reply with a recommended grade, cyclodextrin ratio, sample offer and quotation within one working day.
