High Purity 1H-Indazole-3-carboxylic Acid Methyl Esters (CAS 43120-28-1) - Versatile Synthetic Intermediate for Pharmaceutical Industry

1H-Indazole-3-carboxylic Acid Methyl Esters (CAS 43120-28-1) is a high-value, versatile organic intermediate and crucial building block in modern medicinal chemistry. This ester derivative of indazole-3-carboxylic acid offers excellent solubility and reactivity, making it a preferred starting material for the synthesis of complex bioactive molecules. It is specifically prized for its role in constructing indazole-based pharmacophores, which are central to numerous medical discovery programs targeting a wide range of therapeutic areas.

• Protected Carboxylic Acid Group: The methyl esters acts as a protected form of the carboxylic acid, allowing for more controlled subsequent reactions.
• Versatile Synthetic Intermediate: It is readily subjected to hydrolysis, amidation, reduction, and nucleophilic substitution reactions.
• Core Scaffold Provider: Provides the essential 1H-indazole skeleton, a heterocycle known for its diverse biological activity.
• Building Block for API Synthesis: Directly used in the stepwise construction of potential Active Pharmaceutical Ingredients (APIs).

1H-Indazole-3-carboxylic Acid Methyl Esters is fundamental in research and development across:

• Pharmaceutical Industry: Primary use in the synthesis of medical candidates, especially in areas of:
  • Kinase Inhibitors (for oncology)
  • GPCR Modulators
  • Anti-inflammatory Agents
  • Neurological Disorder Therapeutics
• Agrochemical Research: As an intermediate for novel fungicides or herbicides.
• Academic & Institutional R&D: For methodological studies in heterocyclic chemistry and library synthesis for high-throughput screening.
• Custom Synthesis & Contract Research Organizations (CROs): As a supplied starting material for client-specific molecule synthesis.

We produce 1H-Indazole-3-carboxylic Acid Methyl Esters using state-of-the-art, optimized synthetic routes, typically involving:

1. Starting Material Preparation: From commercially available indazole derivatives or via cyclization of precursor molecules.
2. Esterification: Controlled reaction of the 3-carboxylic acid moiety with methanol under catalytic or activating conditions.
3. Purification: Multi-stage purification including recrystallization and/or column chromatography to achieve high chemical purity.
4. Quality Control: Rigorous analysis via HPLC, NMR (¹H & ¹³C), and Mass Spectrometry to confirm identity, purity, and consistency batch-to-batch.
5. Packaging: Under controlled environment into sealed, labeled containers for safe transport.

• High-Purity & Consistent Quality: Every batch is backed by comprehensive analytical data (CoA).
• Technical Expertise: Deep understanding of indazole chemistry and custom synthesis capabilities.
• Scalable Supply: From gram-scale for research to kilogram-scale for development.
• Competitive Pricing: Direct manufacturing ensures cost-effective supply.
• Global Logistics: Reliable and compliant international shipping.
• Expert Support: Our technical team provides direct support for your synthetic challenges.

We routinely supply ≥98% purity (HPLC), with ≥99% available upon request for critical applications.

Yes. Our strength is custom synthesis. We can synthesize a wide range of indazole-3-carboxylate esters (ethyl, propyl, etc.) or further functionalized derivatives.

Yes. A comprehensive Certificate of Analysis (CoA) including HPLC report and key spectral data (¹H NMR) is provided with every shipment.

When stored sealed at 2-8°C, the product has a shelf life of at least 2 years.

Absolutely. Our manufacturing process is designed for scalability, and we can reliably supply kilogram quantities with consistent quality.

Standard packaging is in double-sealed plastic bags within aluminum foil bags, placed in sturdy cardboard boxes. Sizes range from 1g, 5g, 10g, 100g up to 1kg.